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VaZyMolO Interfaces provides a BLAST engine and a browser to our module sequence library.
VaZyMolO is a database dealing with viral sequences at the proteic level. Its aim is to define modules suitable for high expression , solubility and crystalisation. Thus it integrates tools starting from amino acids composition, hydrophobic clusters analysis, secondary prediction, modelling, homology with solved structures, data mining concerning biochemestry (function and motifs , active sites , cleavage sites etc). Domains are defined on the structural definition of a domain (which can fold by themselves and show activity); but a module can be constituted by several domains.
How VaZyMolO is organised ?
Three layers in VaZyMolO
Virions are organised into three layers: surface proteins, matrix proteins, and non-structural proteins. The VaZyMolO database organisation has been directly inspired by this organisation and is therefore organised into three layers reflecting surface (layer S), matrix (layer M), and non-structural proteins (layer F).
Image: Original virion representation with courtesy of PVL Laboratory,
Dept. of Biological Sciences, University of Warwick, Coventry, UK.
How to start ?
There are 2 ways to use the VaZyMolO interfaces:
- You can seek for information by using our database browser available from the tab entitled "VaZyMolO Browser". Click on a protein name or id to access modular information. Then click on a module to get further details about it.
- If you already have a sequence of interest, you can use our "VaZyMolO Blast and tools" that will enable you with the use of several tools for sequence analysis and a BLAST engine against our database that will retrieve similarities with our data.