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VaZyMolO Interface is a BLAST engine to our module sequence library.
VaZyMolO is a database dealing with viral sequences at the proteic level. Its aim is to define modules suitable for high expression , solubility and crystalisation. Thus it integrates tools starting from amino acids composition, hydrophobic clusters analysis, secondary prediction, modelling, homology with solved structures, data mining concerning biochemestry (function and motifs , active sites , cleavage sites etc). Domains are defined on the structural definition of a domain (which can fold by themselves and show activity); but a module can be constituted by several domains.
How VaZyMolO is organised ?
Three layers in VaZyMolOVirions are organised into three layers: surface proteins, matrix proteins, and non-structural proteins. The VaZyMolO database organisation has been directly inspired by this organisation and is therefore organised into three layers reflecting surface (layer S), matrix (layer M), and non-structural proteins (layer F).
Image: Original virion representation with courtesy of PVL Laboratory,
Dept. of Biological Sciences, University of Warwick, Coventry, UK.